Gordon Rule

Address:
Department of Biological Sciences
Carnegie Mellon University
4400 Fifth Ave, Pittsburgh, PA 15213

Phone: 412-268-1839
Fax: 412-268-7129
Email: rule@andrew.cmu.edu
Homepage: Visit

PhD.: Carnegie Mellon University – 1981-1986
Postdoc: Stanford University, 1986-88

Research:

My research is directed at understanding inter-molecular interactions in biological systems. An understanding of these interactions is required if biological systems are to be comprehended at the molecular level. The combined tools of molecular biology, NMR spectroscopy and x-ray crystallography are used to provide important information to aid in our understanding of these interactions. Our research efforts have been directed at enzyme-substrate interactions, protein-lipid interactions, antibody-antigen interactions, and protein-nucleic acid interactions. Our current interests are directed towards a group of cellular detoxification enzymes: glutathione transferases. This enzymes play an important role in the protection of an organism from carcinogens and other toxic chemicals. Efforts in my laboratory are directed at correlating substrate specificity and enzymatic mechanism with protein dynamics and substrate-protein interactions.