Macromolecular Recognition

Research in this area is focused on elucidating the mechanisms of interactions between molecules – enzyme-substrate, protein-DNA, and protein-ligand. These studies focus on detailed characterization of the exquisite specificity between molecules and how this is achieved, from the point of recognition to attaining high affinity. Additional studies focus on mechanisms by which reactions proceed, from a structural perspective.

Participating Faculty in this Area:

• William Furey, Enzyme crystallography
• Angela Gronenborn, Structure, dynamics and energetics of protein-carbohydrate interactions
• Linda Jen-Jacobson, Specificity & energetics of protein - DNA interactions
• Judith Klein-Seetharaman, Membrane receptor - protein interactions
• Miguel Llinas, NMR of metalloproteins
• John Rosenberg, DNA recognition by X-ray & statistical mechanics
• Gordon Rule, Protein ligand interactions by NMR
• Joanne Yeh, Soluble and Membrane Enzymes, Membrane Receptors and Protein Substrates by X-ray Crystallography